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Fluorinated motifs are ubiquitous in pharmaceuticals and agrochemicals,with approximately 20% of marketed small molecule drugs containing one or more fluorine atoms. Incorporation of fluoroalkyl groups into drug candidates can enhance chemical and metabolic stability,improve lipophilicity and bioavailability,as well as increase protein binding affinity. Hence,the development of general and practical methodologies to construct organofluorine compounds has attracted extensive research interest,and the design,synthesis,and reaction development of novel fluoroalkylation reagents represent one of the most powerful strategies for constructing organofluorine compounds.Hydroxylamine derivatives are versatile building blocks for installing nitrogenand oxygen-containing functional groups via C—N and C—O bond formation.Owing to the low bond dissociation energy of the N—O bond,these compounds can be readily activated under mild conditions,such as transition-metal catalysis,chemical reduction,photocatalytic reduction,heating or ultraviolet irradiation,to generate nitrogen-and oxygen-centered radicals or anions. In recent years,fluoroalkyl hydroxylamine reagents have shown great potential for the construction of nitrogen-and oxygen-containing organofluorine compounds.This review summarizes representative advances in the design,synthesis and application of fluoroalkyl hydroxylamine reagents over the past decade,including N-fluoroalkoxybenzoimidazoles,N-fluoroalkoxypyridiniums,Nfluoroalkoxybenzotriazoliums,O-fluoroalkyl oximes,N-fluoroalkoxyphthalimides,N-fluoroalkylhydroxylamines.
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Basic Information:
DOI：10.13822/j.cnki.hxsj.2026.0124
China Classification Code:TQ421.12
Citation Information:
[1]SHOU Jia-yi,QING Feng-ling.Recent Advances in Fluoroalkyl Hydroxylamine Reagents[J].Chemical Reagents,2026,48(10):1-9.DOI:10.13822/j.cnki.hxsj.2026.0124.
Fund Information:
中国科学院基础与交叉前沿科研先导专项项目(XDB1640000); 青年科学基金项目(22301306)
2026-05-26
2026
2026-06-25
2026-06-29
2026
1
2026-07-03
2026-07-03
2026-07-03